Botox and Dysport / Azzalure are distinct molecular formulations of Botulinum Toxin kind A. Each have a extended (more than 20 several years) of recognized medical use. It was by now recognized that 1 device of Botox is not equivalent to 1 unit of Dysport /Azzalure. In Europe the advice is to use 2.5 models of Dysport / Azzalure for each and every 1 unit of Botox. But there has been extremely little true scientific analysis to substantiate this suggestion.
A study of 62 sufferers in 2006 confirmed that both therapies were being helpful in treating wrinkles. Nevertheless it confirmed that Botox was greater in conditions of wrinkle enhancement and the duration of effect at 16 weeks than Dysport for forehead wrinkles when the ratio of Botox to Dysport/Azzalure was 1:2.5. The authors reported that this research was economically supported by Allergan, the makers of Botox.
Having said that, an additional review was finished in 2007 on 26 people today. This time a 1:3 ratio of Botox to Dysport/Azzalure was made use of so unfortunately it is not specifically comparable with the 2006 study. Even so, this review confirmed that Dysport/Azzalure was superior to Botox with improved period of effect at 20 weeks soon after injection. The authors claimed that this review did not acquire financial backing from any of the brands. This research also provided electrical measurements of muscle exercise as well as digital photographic appraisals performed by an impartial panel of 3 examiners who assessed with brow wrinkles of the persons in the review.
The conclusions that can be drawn from these scientific studies is that there is no apparent greatest sort of Botulinum toxin for cosmetic use. The efficacy of the two products in phrases of their beauty results is well tested as is their safety record. The period of action is dependent to a substantial extent on how several models are administered. If 3 models of Dysport/Azzalure are utilized for each and every a single device of Botox, then the study implies a slightly lengthier duration of effect than Botox, and the reverse would seem to be accurate when the encouraged 2.5:1 ratio is made use of.
In phrases of other facets of individual satisfaction, specially the rapidity of onset of impact and relative incidence of facet effects there is no study to tutorial conclusions. Median time to onset of effect is from day 3 for equally products and solutions and reaches maximal impact at working day 30.